Estrogen receptor specificity for the effects of estrogen in ovariectomized mice
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چکیده
منابع مشابه
Estrogen receptor specificity for the effects of estrogen in ovariectomized mice.
Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 micro g/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal eff...
متن کاملEffects of selective estrogen receptor agonists on estrogen receptor expression in the uterus of ovariectomized rats
The aim of the present study was to investigate effects of short time treatment with estrogen receptor (ER) selective agonists on ERα, ERβ and G-protein coupled estrogen receptor-1 (GPER) expression in the uterus of ovariectomized rats. The rats were treated with either estradiol (E2), the specific ERα agonist PPT or the specific ERβ agonist DPN for 18 hrs. Uterine weights were higher after E2 ...
متن کاملEffects of treadmill exercise training on cerebellar estrogen and estrogen receptors, serum estrogen, and motor coordination performance of ovariectomized rats
Objective(s): The present study aims at examining the motor coordination performance, serum and cerebellar estrogen, as well as ERβ levels, of ovariectomized rats (as menopausal model) following regular exercise. Materials and Methods:Ten female Sprague Dawley ratsaged 12 weeks old were randomly divided into two groups; all of which underwent ovariectomy. The first group was treated with regula...
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The two known estrogen receptors, ERa and ERb, mediate the effects of estrogen in all target tissues, including blood vessels. We have shown previously that estrogen inhibits vascular injury response to the same extent in female wild-type (WT), ERa knockout (ERaKOCH), and ERb knockout (ERbKOCH) mice. We generated mice harboring disruptions of both ERa and ERb genes (ERa,bKOCH) by breeding and s...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2002
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1740167